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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | CS-P1276A |
| 用途 | 分析检测 |
| 包装规格 | 1mg |
| 纯度 | 99%% |
| CAS编号 | |
| 是否进口 | 否 |
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Men 10376 TFA 是一种有效的选择性的?tacCSkinin NK-2?受体拮抗剂，对大鼠小肠 NK-2 受体的?Ki?值为 4.4 μM。
| Description | Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor[1] . |
|---|---|
| IC50 & Target | Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1] |
| In Vitro | Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1] . Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| In Vivo | Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Molecular Weight | 1195.25 |
| Formula | C??H??F?N??O?? |
| Sequence | Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2 |
| Sequence Shortening | DY-{d-Trp}-V-{d-Trp}{d-Trp}-K-NH2 |
| Shipping | Room temperature in continental US; may vary elsewhere. |
| Storage | Protect from light Powder-80°C2 years-20°C1 year *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Solvent & Solubility | In Vitro: H2O : 1.43 mg/mL (1.20 mM; Need ultrasonic) Preparing ConcentrationSolventMass1 mg5 mg10 mg1 mM0.8366 mL4.1832 mL8.3665 mL5 mM---------10 mM--------- * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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