κ-opioid receptor^[1]
IC50: 42.0 μM (NMDA receptor)^[2]

Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds in the transmembrane domain of the κ-receptor^[1] . The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC₅₀ is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks I_NMDA to a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) and DynA(1-10) both exert voltage-independent actions on NMDA receptors^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1348.48

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Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro

YGGFLRRIRP

Room temperature in continental US; may vary elsewhere.

Powder-80°C2 years-20°C1 yearIn solvent-80°C6 months-20°C1 month

In Vitro: 

H₂O : 5 mg/mL (3.71 mM; Need ultrasonic)

Preparing 
Stock Solutions

ConcentrationSolventMass1 mg5 mg10 mg1 mM0.7416 mL3.7079 mL7.4158 mL5 mM---------10 mM---------

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

• [1]. Paterlini G, et al. Molecular simulation of dynorphin A-(1-10) binding to extracellular loop 2 of the kappa-opioidreceptor. A model for receptor activation. J Med Chem. 1997 Sep 26;40(20):3254-62.

  [2]. Chen L, et al. Dynorphin block of N-methyl-D-aspartate channels increases with the peptide length. J Pharmacol Exp Ther. 1998 Mar;284(3):826-31.