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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | CS-P1714A |
| 用途 | 分析检测 |
| 包装规格 | 1mg |
| 纯度 | 99%% |
| CAS编号 | |
| 是否进口 | 否 |
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Apraglutide TFA (FE 203799 TFA) 是一种合成的33-氨基酸肽和长效的 GLP-2类似物，能够增强全回肠切除的新生短肠综合征小猪的适应性和线性肠生长。
| Description | Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum[1] . |
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| In Vivo | Apraglutide (FE 203799; 5 mg/kg/dose, subcutaneously, twice on days 0 and 4 postsurgery) treated piglets are healthy, have significant lower fecal fat and energy losses and exhibite intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth on day 7[1] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:NewbornDuroc piglets, 2-5 days old and weighing between 2-2.6 kg[1].Dosage:5 mg/kg/dose.Administration:Subcutaneously, twice on days 0 and 4 postsurgery.Result:On day 7, treated piglets were healthy, had significant lower fecal fat and energy losses and exhibited intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth. |
| Clinical Trial | NCT NumberSponsorConditionStart DatePhaseNCT03408132GlyPharma Therapeutics|VectivBio AGSBS - Short Bowel SyndromeMay 2, 2018Phase 1|Phase 2NCT03417765GlyPharma Therapeutics|VectivBio AGLymphoma, Non-Hodgkin′s, Adult|Lymphoma, Hodgkin′s, AdultSeptember 1, 2018Phase 1|Phase 2NCT03415594GlyPharma Therapeutics|VectivBio AGShort Bowel SyndromeMay 8, 2018Phase 1|Phase 2 |
| Molecular Weight | 3879.27 |
| Formula | C???H???N??O??.C?HF?O? |
| Sequence | His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Nle-D-Phe-Thr-Ile-Leu-Asp-Leu-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-NH2 |
| Sequence Shortening | HGDGSFSDEX FTILDLLAAR DFINWLIQTK ITD-NH2 |
| Shipping | Room temperature in continental US; may vary elsewhere. |
| Storage | Powder-80°C2 years-20°C1 yearIn solvent-80°C6 months-20°C1 month |
| Solvent & Solubility | In Vitro: H2O Peptide Solubility and Storage Guidelines: 1. Calculate the length of the peptide. 2. Calculate the overall charge of the entire peptide according to the following table: ContentsAssign valueAcidic amino acidAsp (D), Glu (E), and the C-terminal -COOH.-1Basic amino acidArg (R), Lys (K), His (H), and the N-terminal -NH2+1Neutral amino acidGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0 3. Recommended solution: Overall charge of peptideDetailsNegative (<0)1. Try to dissolve the peptide in water first.2. If water fails, add NH4OH (<50 μL).3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.Positive (>0)1. Try to dissolve the peptide in water first.2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.Zero (=0)1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
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