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GP(33-41)
  • 品牌:Chemstan
  • 产地:中国
  • 货号:CS-P0323
  • cas:161928-86-5
  • 发布日期: 2020-11-24
  • 更新日期: 2025-09-19
产品详请
产地 中国
品牌 Chemstan
货号 CS-P0323
用途 分析检测
包装规格 1mg
纯度 99%%
CAS编号 161928-86-5
是否进口

GP(33-41) 是一种由 9 个氨基酸残基组成的多肽,它是淋巴细胞性脉络丛脑膜炎病毒 GP1 抗原决定基中的*序列,能够上调 RMA-S (Db Kb) 细胞表面 H-2Db分子,SC50值为 344 nM。

Description

GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2Dbmolecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM[1] .

In Vitro

GP(33-41) sensitizes MC57 and T2-Db cells to lysis with ED50s of 0.9±0.6 and 2.5±0.7 nM[1]
The interaction between T cell receptors (TCR) and peptide-major histocompatibility complex (pMHC) antigens can lead to varying degrees of agonism (T cell activation), or antagonism. The P14 TCR recognises the lymphocytic choriomeningitis virus (LCMV)-derived peptide, GP(33-41) (KAVYNFATC), presents in the context of H-2D[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

226.98

Formula

CTFKNVY

CAS No.

161928-86-5

Sequence

Lys-Ala-Val-Tyr-Asn-Phe-Ala-Thr-Cys

Sequence Shortening

KAVYNFATC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • [1]. Gairin JE, et al. Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes. J Virol. 1995 Apr;69(4):2297-305.

    [2]. Boulter JM, et al. Potent T cell agonism mediated by a very rapid TCR/pMHC interaction. Eur J Immunol. 2007 Mar;37(3):798-806.


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