Research Grade Abciximab ( 阿昔单抗 )
- 发布日期： 2020-10-28
- 更新日期： 2025-10-28
产品详请
| 产地 |
中国
|
| 品牌 |
Chemstan
|
| 货号 |
CSD00074
|
| 保存条件 |
store at -80℃
|
| 用途 |
仅用于科研用途
|
| 应用范围 |
|
| 抗原来源 |
CHO cells
|
| CAS编号 |
143653-53-6
|
| 保质期 |
一年
|
| 抗体名 |
Abciximab ( 阿昔单抗 )
|
| 是否单克隆 |
否
|
| 克隆性 |
|
| 靶点 |
ITGA2B_ITGB3[Homo sapiens]
|
| 适应物种 |
|
| 形态 |
|
| 宿主 |
|
| 标记物 |
|
| 包装规格 |
mg/ml
|
| 纯度 |
%
|
| 亚型 |
|
| 标识物 |
|
| 浓度 |
95%
|
| 免疫原 |
|
| 是否进口 |
否
|
货号（Catalog No.）
CSD00074
通用名INN
Abciximab
纯度(Purity)
>95%
浓度( Concentration)
1mg/ml
Formulation
PBS buffer pH7.5
Source
CHO cells
内毒素(Endotoxin level)
Please contact with the lab for this information.
生物活性
产品描述(Description)
Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3.Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen,von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and smooth muscle cells.Abciximab binds to the intact platelet GPIIb/IIIa receptor,which is a member of the integrin family of adhesion receptors and the major platelet surface receptor involved in platelet aggregation.This binding is thought to involve steric hindrance and/or conformational alterations which block access of large molecules to the receptor rather than direct interaction with the RGD (arginine-glycine-aspartic acid) binding site of GPIIb/IIIa.By binding to the vitronectin receptor (also known as the αvβ3 integrin), abciximab blocks effects mediated by this integrin which include cell adhesion.Furthermore, abciximab blocks Mac-1 receptor on monocytes and neutrophils thus inhibiting monocyte adhesion.
别名(Alternative names)
c7E3
靶点;物种(Specificity target name;species)
ITGA2B_ITGB3[Homo sapiens]
种类(Species)
Chimeric
受体鉴定(Receptor identification)
Fab-G1-kappa
化学信息
分子量(MV)
145651.1 Da
CAS
143653-53-6
存储条件(Storage)
store at -80°C
Note
For research use only. Not suitable for clinical or therapeutic use.
