货号（Catalog No.）

CSD00079

通用名INN

Cetuximab

纯度(Purity)

>95%

浓度( Concentration)

1mg/ml

Formulation

PBS buffer PH7.5

Source

CHO cells

内毒素(Endotoxin level)

Please contact with the lab for this information.

生物活性

产品描述(Description)

Cetuximab is an epidermal growth factor receptor binding FAB.Cetuximab is composed of the Fv (variable; antigen-binding) regions of the 225 murine EGFr monoclonal antibody specific for the N-terminal portion of human EGFr with human IgG1 heavy and kappa light chain constant (framework) regions.Cetuximab is marketed under the brand Erbitux® by Eli Lilly and Company.In the United States,a regimen of cetuximab costs approximately $30,790 for an eight-week course.Cetuximab binds to the epidermal growth factor receptor (EGFr) on both normal and tumor cells. EGFr is over-expressed in many colorectal cancers.Cetuximab competitively inhibits the binding of epidermal growth factor (EGF) and TGF alpha,thereby reducing their effects on cell growth and metastatic spread.

别名(Alternative names)

Fab C225,IMC-225

靶点;物种(Specificity target name;species)

EGFR[Homo sapiens]

种类(Species)

Chimeric

受体鉴定(Receptor identification)

IgG1-kappa

化学信息

分子量(MV)

145781.6 Da

CAS

205923-56-4

存储条件(Storage)

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.

Note

For research use only .