中文名称:他利珠单抗
CAS No:380610-22-0
分子式:C6518H10020N1728O2036S42

货号（Catalog No.）

CS00020

通用名INN

Natalizumab

纯度(Purity)

>95%

浓度( Concentration)

1mg/ml

Formulation

PBS buffer pH7.5

Source

CHO cells

内毒素(Endotoxin level)

Please contact with the lab for this information.

生物活性

产品描述(Description)

Natalizumab is a recombinant, humanized monoclonal antibody,binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1).Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses.

别名(Alternative names)

AN 100226,BG00002

靶点;物种(Specificity target name;species)

ITGA4/CD49d[Homo sapiens]

活性研究（体外/体内研究）(Activity in vitro)

Natalizumab, a recombinant, humanized antibody, binds to α4β1-integrin and blocks its interaction with VCAM-1. As a result, leukocyte migration into brain tissue is inhibited, reducing inflammation and preventing the formation of lesions. Natalizumab may also inhibit ongoing central nervous system (CNS) inflammation, mediated by leukocytes already present in the CNS, by interrupting the interactions between α4-integrin-expressing leukocytes and extracellular matrix proteins such as fibronectin and osteopontin.

种类(Species)

Humanized

受体鉴定(Receptor identification)

IgG4-kappa

化学信息

CAS

189261-10-7

存储条件(Storage)

store at -80°C