概述（Summary）icon

英文全称

Recombinant Human IL6 protein ,C- Fc tag

纯度（Purity）

>90% as determined by SDS-PAGE

内毒素（Endotoxin level）

Please contact with the lab for this information.

蛋白构建（Construction）

A DNA sequence encoding the human IL6(Met1~Met212) was fused with the C-terminal Fc tag

Accession #

P05231

表达宿主（Host）

Mammalian cells

种属（Species）

Homo sapiens (Human)

预测分子量（Predicted Molecular Mass）

49.8kDa

制剂（Formulation）

Supplied as solution form in 1M Tris-HCl, 0.1M Glycine, pH8.0 or lyophilized from 1M Tris-HCl, 0.1M Glycine, pH8.0.

运输方式（Shipping）

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

稳定性&储存（Stability &Storage）

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

复溶（Reconstitution）

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

电泳图（SDS-PAGE image）icon

活性（Bioactivity）icon

背景（Background）icon

背景介绍

Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.

分子别名（Alternative Names）

IL6,Interleukin-6,BSF2,HSF,IFNB2

参考文献（References）

Spiekermann, Subklewe, Hildebrandt, Humpe, von Bergwelt-Baildon (2020) [COVID-19 from the Perspective of Haematology and Haemostaseology] Deutsche medizinische Wochenschrift (1946) 145(15) 1044-1050