概述（Summary）icon

英文全称

Recombinant Human HAVCR2 protein ,C- His Tag

纯度（Purity）

>90% as determined by SDS-PAGE

内毒素（Endotoxin level）

Please contact with the lab for this information.

蛋白构建（Construction）

A DNA sequence encoding the human HAVCR2(Met1~Arg200) was fused with the C-terminal His Tag

Accession #

Q8TDQ0

表达宿主（Host）

Mammalian cells

种属（Species）

Homo sapiens (Human)

预测分子量（Predicted Molecular Mass）

20.67kDa

制剂（Formulation）

Supplied as solution form in 50 mM Tris-HCl, pH 8.0, 150 mM NaCl or lyophilized from 50 mM Tris-HCl, pH 8.0, 150 mM NaCl.

运输方式（Shipping）

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

稳定性&储存（Stability &Storage）

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

复溶（Reconstitution）

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

电泳图（SDS-PAGE image）icon

背景（Background）icon

背景介绍

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

分子别名（Alternative Names）

HAVCR2,TIM3,TIMD3,FLJ14428,KIM3

参考文献（References）

Kujan, van Schaijik, Farah (2020) Immune Checkpoint Inhibitors in Oral Cavity Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review Cancers 12(7)