概述（Summary）icon

英文全称

Recombinant Human TIGIT protein ,C- His Tag

纯度（Purity）

>90% as determined by SDS-PAGE

内毒素（Endotoxin level）

Please contact with the lab for this information.

蛋白构建（Construction）

A DNA sequence encoding the human TIGIT(Met1~Pro141) was fused with the C-terminal His Tag

Accession #

Q495A1

表达宿主（Host）

Mammalian cells

种属（Species）

Homo sapiens (Human)

预测分子量（Predicted Molecular Mass）

13.99kDa

制剂（Formulation）

Supplied as solution form in PBS, pH7.5 or lyophilized from PBS, pH7.5.

运输方式（Shipping）

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

稳定性&储存（Stability &Storage）

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

复溶（Reconstitution）

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

电泳图（SDS-PAGE image）icon

背景（Background）icon

背景介绍

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

分子别名（Alternative Names）

TIGIT,VSIG9,VSTM3

参考文献（References）

Zhang, Liu (2020) Targeting NK Cell Checkpoint Receptors or Molecules for Cancer Immunotherapy Frontiers in immunology 11() 1295