概述（Summary）icon

英文全称

Recombinant Dog TNF protein ,N- His Tag

纯度（Purity）

>90%by SDS-PAGE

内毒素（Endotoxin level）

Please contact with the lab for this information.

蛋白构建（Construction）

A DNA sequence encoding the Dog TNF (Val77-Leu233）was fused with the N-terminal His Tag

Accession #

P51742

表达宿主（Host）

Mammalian cells

种属（Species）

Canis lupus familiaris (Dog) (Canis familiaris)

预测分子量（Predicted Molecular Mass）

18.27kDa

制剂（Formulation）

Supplied as solution form in PBS, pH7.5 ./ Lyophilized from PBS, pH7.5 .

运输方式（Shipping）

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

稳定性&储存（Stability &Storage）

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

复溶（Reconstitution）

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

背景（Background）icon

背景介绍

Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

分子别名（Alternative Names）

Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2,TNF-a,TNFA, TNFSF2