概述（Summary）icon

英文全称

Recombinant Human IL17A protein , C- His Tag

纯度（Purity）

>90% as determined by SDS-PAGE

内毒素（Endotoxin level）

Please contact with the lab for this information.

蛋白构建（Construction）

A DNA sequence encoding the Human IL17A (Met1-Ala155 ) was fused with the C-terminal His Tag

Accession #

Q16552

表达宿主（Host）

Mammalian cells

种属（Species）

Homo sapiens (Human)

预测分子量（Predicted Molecular Mass）

18.05 kDa

制剂（Formulation）

Supplied as solution form in PBS, pH7.5./ Lyophilized from PBS, pH7.5 .

运输方式（Shipping）

In general, proteins are provided as lyophilized powder. They are shipped out with blue ice unless customers require otherwise.

稳定性&储存（Stability &Storage）

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

活性（Bioactivity）icon

背景（Background）icon

背景介绍

Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

分子别名（Alternative Names）

Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8,CTLA8, IL17,IL-17,