Recombinant Human LRP6 protein
- 价格: ¥1280/支
- 发布日期: 2020-11-03
- 更新日期: 2025-09-19
产品详请
产地 |
中国
|
品牌 |
chemstan
|
货号 |
CSP00130
|
用途 |
科研实验
|
包装规格 |
50ug
|
纯度 |
>90%
|
CAS编号 |
|
是否进口 |
否
|
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.