The Really Interesting New Gene (RING) Finger protein 11 (RNF11) is a subunit of the A2 ubiquitin-editing complex that ensures the transient nature of inflammatory responses. Ring finger protein 11 (RNF11) is a RING (really interesting new gene)-H2 E3 ligase that is overexpressed in several human tumor tissues. The RING E3 ligase RNF11 is a novel GGA cargo actively participating in regulating the ubiquitination of the GGA protein family. RING finger protein 11 (RNF11), a negative regulator of NF-kappaB signaling pathway, colocalizes with alpha-synuclein and is sequestered in Lewy bodies in Parkinson's disease (PD).