GJA1 encodes connexin 43 (Cx43), the most widely expressed gap junction protein. The de novo missense mutations in GJA1 (gap junction protein alpha 1) cause EKVP. Erythrokeratodermia variabilis et progressiva (EKVP) is a rare, inherited skin disease that is characterized by transient figurate patches of erythema, localized or generalized scaling, and frequent palmoplantar keratoderma. GJA1 and SERPINE2 represent potential gene markers associated with oocyte maturation. In the GJA1 gene which encodes gap junction channel protein connexin 43.