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Recombinant Human OTUB2 protein
  • 品牌:chemstan
  • 产地:中国
  • 货号:CSP00451
  • 价格: ¥1280/支
  • 发布日期: 2020-11-03
  • 更新日期: 2025-08-15
产品详请
产地 中国
品牌 chemstan
货号 CSP00451
用途 科研实验
包装规格 50ug
纯度 >90%
CAS编号
是否进口
Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1 and α2, and a large helical region comprised of α3-α1. Like other DUBs, otubain 2 (OTUB2) cleaves proteins precisely at the ubiquitin-protein bond so that ubiquitylation process can be reversed and regulated. Otubain 2 (OTUB2)'s active-site cleft is sterically occluded by a novel loop conformation resulting in an oxyanion hole, which consists uniquely of backbone amides. Furthermore, the residues that orient and stabilize the active-site histidine of otubain 2 (OTUB2) are different from other cysteine proteases. This reorganization of the active-site topology provides a possible explanation for the low turnover and substrate specificity of the otubains.
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