Neurotrophin-3 (NTF3) is a key mediator of neuronal development during the early neurogenic period, as a putative regulatory target of POU3F2. NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation. Neurotrophin 3 (NTF3) is capable of activating TrkB to induce anoikis resistance, and show that NTF3 is also a direct target of miR-2c.