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Recombinant Human IL10RA protein
  • 品牌:chemstan
  • 产地:中国
  • 货号:CSP00744
  • 价格: ¥1280/支
  • 发布日期: 2020-11-03
  • 更新日期: 2025-10-17
产品详请
产地 中国
品牌 chemstan
货号 CSP00744
用途 科研实验
包装规格 50ug
纯度 >90%
CAS编号
是否进口
Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy.
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