Recombinant Human CD177 protein
- 价格: ¥1280/支
- 发布日期: 2020-11-03
- 更新日期: 2025-07-25
产品详请
产地 |
中国
|
品牌 |
chemstan
|
货号 |
CSP01795
|
用途 |
科研实验
|
包装规格 |
50ug
|
纯度 |
>90%
|
CAS编号 |
|
是否进口 |
否
|
In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production . In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration. Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro . However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo . Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils . By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis .