Constitutively active calcium selective cation channel thought to be involved in Ca2+ reabsorption in kidney and intestine . Required for normal Ca2+ reabsorption in the kidney distal convoluted tubules . The channel is activated by low internal calcium level and the current exhibits an inward rectification . A Ca2+-dependent feedback regulation includes fast channel inactivation and slow current decay . Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.