Pyrrolidinedithiocarbamate ammonium(PDTC)-武汉科斯坦生物科技有限公司

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Pyrrolidinedithiocarbamate ammonium(PDTC)

英文名称：Pyrrolidinedithiocarbamate ammonium(PDTC)

品牌：Chemstan

产地：武汉

货号：CS-18738

cas：5108-96-3

价格： ￥500/支
发布日期： 2021-03-10
更新日期： 2025-09-29

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产地	武汉
品牌	Chemstan
货号	CS-18738
用途	科研
英文名称	Pyrrolidinedithiocarbamate ammonium(PDTC)
包装规格	100 mg
纯度	98%%
CAS编号	5108-96-3
别名	1-Pyrrolidinedithiocarboxylic acid ammonium salt,燗PDC,燩DTC,Ammonium pyrrolidinedithiocarbamate,燩yrrolidinedithiocarbamate
分子式	C5H12N2S2
是否进口	否

Description

Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate) is a selective NF-κB inhibitor.

IC₅₀ & Target^[1]

NF-κB

In Vitro

Pretreatment of cells with Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate; 3-1000 μM) dose-dependently attenuate IL-8 production^[1].
Furthermore, pyrrolidinedithiocarbamate ammonium (100 μM) suppresses the accumulation of IL-8 mRNA^[1].
Pyrrolidinedithiocarbamate ammonium inhibits the activation of NF-κB, because it suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate ammonium decrease IL-8 production by intestinal epithelial cells^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

164.29

Formula

C?H??N?S?

CAS No.

5108-96-3

中文名称

吡咯烷二硫代甲酸铵盐；四亚甲基二硫代氨基甲酸铵；1-吡咯烷二硫代羧酸铵盐；吡咯烷二硫代氨基甲酸铵；1-吡咯烷硫代羧酸铵盐；吡咯二硫代甲酸铵；四次甲基二硫代氨基甲酸铵；1-吡咯烷羰基二硫酸铵盐

SMILES

SC(N1CCCC1)=S.N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (304.34 mM; Need ultrasonic)

DMSO : ≥ 42 mg/mL (255.65 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg

1 mM	6.0868 mL	30.4340 mL	60.8680 mL
5 mM	1.2174 mL	6.0868 mL	12.1736 mL
10 mM	0.6087 mL	3.0434 mL	6.0868 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (12.66 mM); Clear solution
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.08 mg/mL (12.66 mM); Clear solution
3.

请依序添加每种溶剂： PBS

Solubility: 24 mg/mL (146.08 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在 MCE 网站选购。

References

[1]. Németh ZH, et al. Pyrrolidinedithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells. Immunol Lett. 2003 Jan 2;85(1):41-6.

[2]. Qin JD, et al. Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and CYP2E1 content of rats with immunological liver injury. Pharm Biol. 2014 Nov;52(11):1460-1466.