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| 产地 | 中国 |
| 品牌 | chemstan |
| 货号 | CS-P2230 |
| 用途 | 科研 |
| 英文名称 | Angstrom6 |
| 包装规格 | 5 mg |
| 纯度 | 99.70%% |
| CAS编号 | 220334-14-5 |
| 别名 | |
| 分子式 | C??H??N??O?? |
| 是否进口 | 否 |
| Description | Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling[1] [2] . |
|---|---|
| In Vitro | Angstrom6 is effective at blocking the migration of the OVCAR8, OVCAR3, ES2, IGROV-1, MDA-MB-468, and MDA-MB361 cells with IC50s in the range of 10 to 100 nM[3] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| In Vivo | Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%[3] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:C57Bl/6 mice (bearing B16-F10 cells)[3]Dosage:100 mg/kgAdministration:S.c.; twice a day for 11 daysResult:Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control. |
| Molecular Weight | 910.97 |
| Formula | C??H??N??O?? |
| CAS No. | 220334-14-5 |
| Sequence | Ac-Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu-NH2 |
| Sequence Shortening | Ac-KPSSPPEE-NH2 |
| Shipping | Room temperature in continental US; may vary elsewhere. |
| Storage | Powder-80°C2 years-20°C1 yearIn solvent-80°C6 months-20°C1 month |
| References |
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