Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active爌urine nucleoside phosphorylase (PNP)爄nhibitor with營C50s of 36 nM, 5 nM, and 32 nM for爃uman, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a燭-cell爌roliferation inhibitor with an營C50爋f 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and燞IV爄nfection treatment