Cearoin-武汉科斯坦生物科技有限公司

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Cearoin

英文名称：Cearoin

品牌：Chemstan

产地：中国

货号：CS-N8418

cas：52811-37-7

价格： ￥100/mg
发布日期： 2021-03-08
更新日期： 2025-09-19

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产地	中国
品牌	Chemstan
货号	CS-N8418
用途	科研
英文名称	Cearoin
包装规格	100 mg
纯度	98.00%%
CAS编号	52811-37-7
别名
分子式	C??H??O?
是否进口	否

Description

Cearoin, isolated from Dalbergia odorifera, increases autophagy and apoptosis through the production of ROS and the activation of ERK^[1].

IC₅₀ & Target^[1]

ERK

ROS

Autophagy

Apoptosis

In Vitro

Cearoin (10-80 μM) induces cell death in a dose-dependent manner^[1].
Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells^[1].
Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Human neuroblastoma SH-SY5Y cells
Concentration:	0, 1, 5, 10, 20, 40, or 80 μM
Incubation Time:	6 or 12 hours
Result:	Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells.

Molecular Weight

244.24

Formula

C??H??O?

CAS No.

52811-37-7

SMILES

O=C(C1=CC(O)=C(OC)C=C1O)C2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1]. Tonking Bastola, et al. Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells. Molecules. 2017 Feb 6;22(2):242.