Cearoin, isolated from Dalbergia odorifera, increases autophagy and apoptosis through the production of ROS and the activation of ERK^[1] .

Cearoin (10-80 μM) induces cell death in a dose-dependent manner^[1] . 
Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells^[1] . 
Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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• [1]. Tonking Bastola, et al. Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells. Molecules. 2017 Feb 6;22(2):242.