EMI1-武汉科斯坦生物科技有限公司

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EMI1

英文名称：EMI1

品牌：Chemstan

产地：中国

货号：CS-138072

cas：35773-42-3

价格： ￥100/mg
发布日期： 2021-03-08
更新日期： 2025-11-03

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产地	中国
品牌	Chemstan
货号	CS-138072
用途	科研
英文名称	EMI1
包装规格	100 mg
纯度	98.00%%
CAS编号	35773-42-3
别名
分子式	C??H??N?O?
是否进口	否

Description

EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor. EMI1 can be used for the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)^[1].

IC₅₀ & Target^[1]

EGFR^{del19 T790M C797S}

EGFR^{L858R/T790M/C797S}

In Vitro

EMI1 inhibits PC9 EGFR ex19del/T790M/C797S organoid growth with the EC₅₀ of 131 nM^[1].
EMI1 (1 nM-10 μM) potently reduces the interaction of EGFR triple mutant with Shc1^[1].
EMI1 (1 nM-100μM) strongly inhibits the viability and increase the caspase 3/7 activity of PC9 EGFR ex19del/T790M/C797S triple-mutant cells than noncancerous human bronchial epithelial (HBE) cells^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	PC9 EGFR ex19del/T790M/C797S and HBE bronchial epithelial lung EGFR-WT control cells.
Concentration:	0.001, 0.01, 0.1, 1, 10, 100 μM
Incubation Time:	72 hours
Result:	Strongly inhibited the viability.

Molecular Weight

334.37

Formula

C??H??N?O?

CAS No.

35773-42-3

SMILES

O=C1C(C2=NC3=CC=CC=C3O2)=CC4=CC=C(N(CC)CC)C=C4O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1]. Punit Saraon, et al. A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat Chem Biol. 2020 May;16(5):577-586.