ICCB280-武汉科斯坦生物科技有限公司

产品展厅

您当前的位置：网站首页 > 产品展厅 >小分子化合物 >ICCB280

ICCB280

英文名称：ICCB280

品牌：Chemstan

产地：中国

货号：CS-134333

cas：2041072-41-5

价格： ￥2500/mg
发布日期： 2021-03-10
更新日期： 2025-09-19

发送咨询信息

产品详请

产地	中国
品牌	Chemstan
货号	CS-134333
用途	科研
英文名称	ICCB280
包装规格	5 mg
纯度	98.00%%
CAS编号	2041072-41-5
别名
分子式
是否进口	否

Description

ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc)^[1]^[2].

IC₅₀ & Target

C/EBPα^[1]

In Vitro

ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC₅₀ of 8.6 μM^[1].
ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells^[1].
ICCB280 (10 μM; 7 d) induces granulocytic differentiation and subsequent apoptosis in HL-60 cells^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	HL-60 cells
Concentration:	0.1, 0.5, 1, 5, 10, 50 μM
Incubation Time:	48 hours
Result:	Induced cell growth arrest, with an IC₅₀ of 8.6 μM.

Molecular Weight

386.40

Formula

C??H??N?O?

CAS No.

2041072-41-5

SMILES

O=C1N(C2=CC=CC=C2OC)C(/C=C/C3=CC=C(O)C(O)=C3)=NC4=C1C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL (215.66 mM; Need ultrasonic)

Preparing
Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg

1 mM	2.5880 mL	12.9400 mL	25.8799 mL
5 mM	0.5176 mL	2.5880 mL	5.1760 mL
10 mM	0.2588 mL	1.2940 mL	2.5880 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.08 mg/mL (5.38 mM); Clear solution
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.38 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。

References

[1]. Radomska HS, et, al. A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation. J Biomol Screen. 2015 Oct;20(9):1150-9.

[2]. Sridhar R, et, al. Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα. Molecules. 2018 Aug 3;23(8):1938.