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Alminoprofen
  • 英文名称:Alminoprofen
  • 品牌:Chemstan
  • 产地:中国
  • 货号:CS-17485
  • cas:39718-89-3
  • 价格: ¥500/mg
  • 发布日期: 2021-03-10
  • 更新日期: 2025-09-19
产品详请
产地 中国
品牌 Chemstan
货号 CS-17485
用途 科研
英文名称 Alminoprofen
包装规格 10 mg
纯度 98.00%%
CAS编号 39718-89-3
别名
分子式
是否进口
Description

Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A2 (sPLA2) and COX-2[1] .

IC50 & Target[1]

sPLA2

COX-2

In Vitro

Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both sPLA2 but also COX-2. Alminoprofen (from 0 to 50 μM) induces a dose-related inhibitory response on thelevels of PGE2 formed by the CRL-1517 cell line[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Alminoprofen (100-300 mg/kg; p.o.) exerts an anti-inflammatory activity[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Groups of Wistar Rats (Oedema of the paw)[1]
Dosage: 100 mg/kg
Administration: P.o.
Result: Exerted a statistically significant dose-dependent antagonist action lasting throughout the 2-hr observation period.
Molecular Weight

219.28

Formula

C??H??NO?

CAS No.

39718-89-3

SMILES

O=C(O)C(C)C1=CC=C(NCC(C)=C)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
  • [1]. Raguenes-Nicol C, et al. Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway. Biochem Pharmacol. 1999;57(4):433-443.

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