Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD-武汉科斯坦生物科技有限公司

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Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD

英文名称：Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD

品牌：Chemstan

产地：中国

货号：CS-113697

cas：1037589-69-7

价格： ￥1300/mg
发布日期： 2021-03-10
更新日期： 2025-11-10

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产品详请

产地	中国
品牌	Chemstan
货号	CS-113697
用途	科研
英文名称	Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD
包装规格	5 mg
纯度	98.00%%
CAS编号	1037589-69-7
别名
分子式
是否进口	否

Description

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Animal Model:	Eight week old Zucker rats^[3]
Dosage:	3?mg/kg and 10?mg/kg
Administration:	Subcutaneously twice a week for two weeks
Result:	There was no change of BW observed, and food intake was not changed in the treated groups compared to control. Caused a significant decrease of glucose excursion during the oral glucose tolerance test (OGTT) compared to control.

Molecular Weight

528.55

Formula

C??H??N?O?

CAS No.

1037589-69-7

SMILES

O=C(CCN1C(C=CC1=O)=O)NCCOCCOCCC(NC2=CC=C(C=C2)CCC(N3C(CC3)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (236.50 mM; Need ultrasonic)

Preparing
Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg

1 mM	1.8920 mL	9.4598 mL	18.9197 mL
5 mM	0.3784 mL	1.8920 mL	3.7839 mL
10 mM	0.1892 mL	0.9460 mL	1.8920 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。

References

[1]. Sonoda J, et al. FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseases. Horm Mol Biol Clin Investig. 2017 May 19;30(2).