2-Methylquinazolin-4-ol-武汉科斯坦生物科技有限公司

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2-Methylquinazolin-4-ol

英文名称：2-Methylquinazolin-4-ol

品牌：Chemstan

产地：中国

货号：CS-W051513

cas：1769-24-0

价格： ￥100/mg
发布日期： 2021-03-10
更新日期： 2025-11-10

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产地	中国
品牌	Chemstan
货号	CS-W051513
用途	科研
英文名称	2-Methylquinazolin-4-ol
包装规格	100 mg
纯度	98.00%%
CAS编号	1769-24-0
别名
分子式
是否进口	否

Description

2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a K_i of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM^[1]^[2].

In Vitro

2-Methylquinazolin-4-ol inhibits ATCase in a concentration-dependent manner^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

2-Methylquinazolin-4-ol (0.2-1 mg; i.g.; for two days) inhibits ATCase in a dosedependent manner in vivo^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice^[2]
Dosage:	0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 1 mg
Administration:	Oral gavage, for two days
Result:	Showed an inhibitory effect upon ATCase.

Molecular Weight

160.17

Formula

C?H?N?O

CAS No.

1769-24-0

中文名称

4-羟基-2-甲基喹唑啉；2-甲基-4(3H)-喹唑酮

SMILES

O=C1NC(C)=NC2=C1C=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (312.17 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg

1 mM	6.2434 mL	31.2168 mL	62.4337 mL
5 mM	1.2487 mL	6.2434 mL	12.4867 mL
10 mM	0.6243 mL	3.1217 mL	6.2434 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

References

[1]. S Yoshida, et al. Production of 2-methyl-4[3H]-quinazolinone, an inhibitor of poly(ADP-ribose) synthetase, by bacterium. J Antibiot (Tokyo). 1991 Jan;44(1):111-2.

[2]. Mahmoud Balbaa, et al. Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives. J Enzyme Inhib Med Chem. 2008 Aug;23(4):483-92.