BAY 73-1449-武汉科斯坦生物科技有限公司

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BAY 73-1449

英文名称：BAY 73-1449

品牌：Chemstan

产地：中国

货号：CS-118941

cas：693790-96-4

价格： ￥3000/mg
发布日期： 2021-03-10
更新日期： 2025-09-19

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产地	中国
品牌	Chemstan
货号	CS-118941
用途	科研
英文名称	BAY 73-1449
包装规格	5 mg
纯度	98.00%%
CAS编号	693790-96-4
别名
分子式
是否进口	否

Description

BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC₅₀ of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 can be used in the research of lowering blood pressure^[1].

IC₅₀ & Target^[1]

IP Receptor

<0.1 nM (IC₅₀)

In Vivo

BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats^[1].
BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats^[1].
BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (250-350 g) are ligated portal vein^[1]
Dosage:	0.1, 1 mg/kg
Administration:	A single i.v.
Result:	Significantly reduced shunt flow without affecting mesenteric flow.

Molecular Weight

425.48

Formula

C??H??N?O?

CAS No.

693790-96-4

SMILES

O=C(O)[C@@H](CC1=CC=CC=C1)NC2=NC=NC(C3=CC=C(OCC4=CC=CC=C4)C=C3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (587.57 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg

1 mM	2.3503 mL	11.7514 mL	23.5029 mL
5 mM	0.4701 mL	2.3503 mL	4.7006 mL
10 mM	0.2350 mL	1.1751 mL	2.3503 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: 2.08 mg/mL (4.89 mM); Suspended solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.89 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。

References

[1]. Bexis S, et, al. Vascular actions of the prostacyclin receptor antagonist BAY 73-1449 in the portal hypertensive rat. Eur J Pharmacol. 2008 Aug 20;590(1-3):322-6.