Direct Violet 1, an azo dye, is a textile dye. Direct Violet 1 is also the protein-protein interaction (PPI) between the SARS-CoV-2 spike protein and ACE2 inhibitor with IC₅₀s of 1.47-2.63 μM^{[1] [2]} .

IC50: 1.47 μM (SARS-CoV-2-S-RBD binding to ACE2); 2.63 μM (SARS-CoV-S1S2 binding to ACE2); 2.11 μM (TNF-R1-TNFα binding)^[1]

Direct Violet 1 inhibits SARS-CoV-2-S-RBD binding to human ACE2, inhibits SARS-CoV-S1S2 binding to ACE2, and inhibits TNF-R1 binding to TNFα with IC₅₀ values of 1.47 μM, 2.63 μM, and 2.11 μM, respectively^[1] .
Direct Violet 1 inhibits SARS-CoV-2 pseudovirus entry into hACE2 expressing host cells in a concentration-dependent manner with an IC₅₀ of 35.8 μM^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

728.66

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2586-60-9

直接青莲N；直接紫1；直接紫N

O=S(C1=CC(O)=C2C(/N=N/C3=CC=C(C4=CC=C(/N=N/C5=C(N)C=CC6=CC(S(=O)(O[Na])=O)=CC(O)=C56)C=C4)C=C3)=C(N)C=CC2=C1)(O[Na])=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Damir Bojadzic, et al. Small-Molecule In Vitro Inhibitors of the Coronavirus Spike-ACE2 Protein-Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2. bioRxiv, 2020 Oct 22.

  [2]. Wafaa M Abd El-Rahim, et al. Genotoxicity studies on the removal of a direct textile dye by a fungal strain, in vivo, using micronucleus and RAPD-PCR techniques on male rats. J Appl Toxicol. 2008 May;28(4):484-90.