(Rac)-Lanicemine-武汉科斯坦生物科技有限公司

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(Rac)-Lanicemine

英文名称：(Rac)-Lanicemine

品牌：Chemstan

产地：中国

货号：CS-108235B

cas：61890-25-3

价格： ￥500/mg
发布日期： 2021-03-10
更新日期： 2025-09-19

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产地	中国
品牌	Chemstan
货号	CS-108235B
用途	科研
英文名称	(Rac)-Lanicemine
包装规格	10 mg
纯度	98.00%%
CAS编号	61890-25-3
别名
分子式
是否进口	否

Description

(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (K_i of 0.56-2.1?μM for NMDA receptor; IC₅₀s of 4-7?μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects^[1].

IC₅₀ & Target

NMDA receptor^[1]

In Vivo

Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects^[1]. Lanicemine (3, 10 or 30?mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	3, 10 or 30?mg/kg
Administration:	Intraperitoneal
Result:	Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity.

Molecular Weight

198.26

Formula

C??H??N?

CAS No.

61890-25-3

中文名称

(Rac)-拉尼西明

SMILES

NC(C1=CC=CC=C1)CC2=NC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (504.39 mM; Need ultrasonic)

Preparing
Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg

1 mM	5.0439 mL	25.2194 mL	50.4388 mL
5 mM	1.0088 mL	5.0439 mL	10.0878 mL
10 mM	0.5044 mL	2.5219 mL	5.0439 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (12.61 mM); Clear solution
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (12.61 mM); Clear solution
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (12.61 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。

References

[1]. Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85.