bpV(phen) trihydrate, a insulin-mimetic agent, is a potent?protein tyrosine phosphatase (PTP)?and?PTEN?inhibitor with?IC50s of 38 nM, 343 nM and 920 nM for?PTEN,?PTP-β?and?PTP-1B, respectively. bpV(phen) trihydrate inhibits proliferation of the protozoan?parasite?Leishmania?in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a?Th1-typepathway (IL-12, IFNγ). bpV(phen) trihydrate can also induce cell?apoptosis, and has anti-angiogenic and anti-tumor activity