Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke.

Neuronal injury in ischemic stroke is partly mediated by cytotoxic reactive oxygen species. Although the antioxidant ascorbic acid (AA) or vitamin C does not penetrate the blood-brain barrier (BBB), its oxidized form, dehydroascorbic acid (DHA), enters the brain by means of facilitative transport^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

174.11

C?H?O?

490-83-5

脱氢抗坏血酸

OC[C@@H]([C@](O1)([H])C(C(C1=O)=O)=O)O

Room temperature in continental US; may vary elsewhere.

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• [1]. Huang J, et al. Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potentcerebroprotection in experimental stroke. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11720-4.