Levocabastine (R 50547) hydrochloride is a long acting, highly potent and selective histamine H1-receptor antagonist with anti-allergic activity. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a K_i of 17 nM for mNTR2^{[1] [2]} .

Levocabastine (0.25 mg/kg; i.p.; twice a day for five successive days; guinea-pigs) inhibits the virus-induced airway hyperresponsiveness, suppresses the influx of broncho-alveolar cells and increase in albumin content, and corrects the reduced chemiluminescence production by broncho-alveolar cells in response to zymosan^[1] .
In mice that receivedβ-LT, Levocabastine (0.05 mg/kg; i.p.) blocks the anxiolytic effect of β-LT and the number of head-dips decreased^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Room temperature in continental US; may vary elsewhere.

• [1]. Folkerts G, et al. Virus-induced airway hyperresponsiveness in the guinea-pig: possible involvement of histamine and inflammatory cells. Br J Pharmacol. 1993;108(4):1083-1093.

  [2]. Yamauchi R, et al. Effect of beta-lactotensin on acute stress and fear memory. Peptides. 2006;27(12):3176-3182.