S-Methylisothiourea sulfate-武汉科斯坦生物科技有限公司

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S-Methylisothiourea sulfate

英文名称：S-Methylisothiourea sulfate

品牌：Chemstan

产地：中国

货号：CS-79457

cas：867-44-7

价格： ￥500/mg
发布日期： 2021-03-10
更新日期： 2025-11-10

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产地	中国
品牌	Chemstan
货号	CS-79457
用途	科研
英文名称	S-Methylisothiourea sulfate
包装规格	25 mg
纯度	98.00%%
CAS编号	867-44-7
别名
分子式
是否进口	否

Description

S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock^[1].

IC₅₀ & Target

iNOS^[1]

In Vitro

S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site^[1].
S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages^[1].
S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells^[1].
S-Methylisothiourea sulfate(up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

S-Methylisothiourea sulfate (0.01-3 mg/kg; i.v.) dose-dependently reverses the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin LPS in anesthetized rats^[1].
S-Methylisothiourea sulfate (5 mg/kg; i.p.; given 2 hr after LPS; 10 mg/kg, i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS^[1].
S-Methylisothiourea sulfate (1 mg/kg; i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg; i.p.)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (260-320 g)^[1]
Dosage:	0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg
Administration:	Intravenous injection
Result:	Caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats; Inhibits iNOS activity measured in homogenates of lung.

Molecular Weight

139.18

Formula

C?H?N?S.?/?H?O?S

CAS No.

867-44-7

中文名称

S-甲基异硫脲半硫酸盐

SMILES

NC(SC)=N.O=S(O)(O)=O.[1/2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 65 mg/mL (467.02 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg

1 mM	7.1849 mL	35.9247 mL	71.8494 mL
5 mM	1.4370 mL	7.1849 mL	14.3699 mL
10 mM	0.7185 mL	3.5925 mL	7.1849 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

References

[1]. C Szabó, et al. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26): 12472–12476.