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Sepimostat dimethanesulfonate
  • 英文名称:Sepimostat dimethanesulfonate
  • 品牌:Chemstan
  • 产地:中国
  • 货号:CS-136299A
  • cas:103926-82-5
  • 价格: ¥3000/mg
  • 发布日期: 2021-03-10
  • 更新日期: 2025-09-19
产品详请
产地 中国
品牌 Chemstan
货号 CS-136299A
用途 科研
英文名称 Sepimostat dimethanesulfonate
包装规格 5 mg
纯度 98.00%%
CAS编号 103926-82-5
别名
分子式
是否进口
Description

Sepimostat dimethanesulfonate (FUT-187) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7?μM[1] .

In Vivo

Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats weighing 150-300?g[1] .
Dosage: Intravitreal injection.
Administration: 1 to 100 nmol/eye.
Result: Exhibited neuroprotective effects significantly.
Molecular Weight

565.62

Formula

C??H??N?O?S?

CAS No.

103926-82-5

SMILES

O=C(OC1=CC=C2C=C(C(N)=N)C=CC2=C1)C3=CC=C(NC4=NCCN4)C=C3.CS(=O)(O)=O.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • [1]. Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409.

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