Metamizole sodium-武汉科斯坦生物科技有限公司

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Metamizole sodium

英文名称：Metamizole sodium

品牌：Chemstan

产地：中国

货号：CS-B1279A

cas：68-89-3

价格： ￥1000/mg
发布日期： 2021-03-10
更新日期： 2025-11-10

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产地	中国
品牌	Chemstan
货号	CS-B1279A
用途	科研
英文名称	Metamizole sodium
包装规格	100 mg
纯度	98.00%%
CAS编号	68-89-3
别名
分子式
是否进口	否

Description

Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole (sodium) is a cyclooxygenase-3 (COX-3) inhibitor^[1]^[2].

IC₅₀ & Target

COX-3^[2]

In Vitro

Metamizole sodium inhibits COX-3 with IC₅₀ value of 52 μM and COX-1 at a 6.6-fold higher concentration in insect cells^[2].
Metamizole (1-500 μM; 48 hours) significantly inhibits cell proliferation in pancreatic cancer cells^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[3]

Cell Line:	Pancreatic cancer cell lines PaTu 8988t and Panc-1
Concentration:	1 μM, 10 μM, 100 μM, 250 μM, 500 μM
Incubation Time:	48 hours
Result:	Significantly inhibited cell proliferation in the PaTu 8988t cell line; significantly inhibited cell proliferation in the pancreatic cancer cell line Panc-1 at 1-250 μM.

In Vivo

Metamizole sodium (500 mg/kg; i.p.; twice a day; for 7 days) diminishes the development of neuropathic pain symptoms in rats^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (270-300 g), with peripheral neuropathic pain^[4]
Dosage:	500 mg/kg
Administration:	Intraperitoneal injection, twice a day, for 7 days
Result:	Diminished the expression of pronociceptive interleukins (IL-1beta, IL-6, and IL-18) and chemokines (CCL2, CCL4, and CCL7) in DRG measured 7 days after sciatic nerve injury.

Molecular Weight

333.34

Formula

C??H??N?NaO?S

CAS No.

68-89-3

中文名称

安乃近

SMILES

O=S(CN(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)C)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1]. A Jasiecka, et al. Pharmacological characteristics of metamizole. Pol J Vet Sci. 2014;17(1):207-14.

[2]. N V Chandrasekharan, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21): 13926–13931.

[3]. Manuela Malsy, et al. Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1. BMC Pharmacol Toxicol. 2017 Dec 6;18(1):77.

[4]. Renata Zajaczkowska, et al. Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain. Pharmacol Rep. 2020 Oct;72(5):1310-1322.