Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from Ellipticine (HY-15753). Datelliptium chloride hydrochloride is effective in vivo against a variety of murine solid tumors^{[1] [2]} .

Datelliptium chloride hydrochloride shows cytotoxic effects after 2 hours of treatment in suspension and primary cultures of rat hepatocytes^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Datelliptium chloride hydrochloride has broad antitumor activity against solid tumors of mice in vivo^[2] .
Datelliptium chloride hydrochloride (170 mg/kg; i.v; for 12 days) exhibits a high degree of antitumor activity at early staged disease^[2] .
Datelliptium chloride hydrochloride is selectively cytotoxic for solid tumors over leukemia L1210^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

434.40

C??H??Cl?N?O

157000-76-5

[H]Cl.CC1=C2C(NC3=C2C=C(O)C=C3)=C(C)C4=CC=[N+](CCN(CC)CC)C=C41.[Cl-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Donato MT, et al. Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicol In Vitro. 1992 Jul;6(4):295-302.

  [2]. Mucci-LoRusso P, et al. Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice. Invest New Drugs. 1990 Aug;8(3):253-61.