SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC₅₀ of 6.5 nM and a K_d of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC₅₀ of 1000 nM)^[1] .

IC50: 6.5 nM (SMS2), 1000 nM (SMS1)^[1]
Kd: 37 nM (SMS2)^[1]

AS/MS binding experiments are conducted using these SMS2-mutant membrane fractions, SMS2-IN-1 (compound 2) binds to the S217A, H272A, and D276A mutants. S227 and H229 are pivotal amino acid residues for the binding of SMS2-IN-1 to SMS2^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Adachi R, et al. Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors. Eur J Med Chem. 2017 Aug 18;136:283-293.