MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC₅₀ of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC₅₀ of 4.0 nM in IMR-32 cells^[1] .

IC50: 65 nM (melanin concentrating hormone receptor 1), 4.0 nM (hERG in IMR-32 cells)^[1]

MCHR1 antagonist 2 (Compound 30) is an antagonist of melanin concentrating hormone receptor 1, with an IC₅₀ of 65 nM. MCHR1 antagonist 2 has inhibitory effects on Ca²⁺ flux, and hERG, with IC₅₀s of 196?±?30 nM and 4.0?±?0.8 nM, respectively, in IMR-32 cells^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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863115-70-2

O=C(C1=CC(C2=CC(F)=CC=C2O1)=O)NC3CCN(CC4=CC=C(OCO5)C5=C4)CC3

Room temperature in continental US; may vary elsewhere.

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• [1]. Lynch JK, et al. Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety. J Med Chem. 2006 Nov 2;49(22):6569-84.