NITD-2, a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly^[1] .

NITD-2 inhibits de novo RNA synthesis^[1] .
NITD-2 exhibited no antiviral activity in cell culture resulted from the poor cell penetratration^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

433.48

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1197896-79-9

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pornwaratt Niyomrattanakit, et al. Inhibition of dengue virus polymerase by blocking of the RNA tunnel. J Virol. 2010 Jun;84(11):5678-86.