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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | CS-N7395A |
| 用途 | 科研 |
| 英文名称 | Cyclic ADP-ribose ammonium |
| 包装规格 | 500 μg |
| 纯度 | 98.00%% |
| CAS编号 | |
| 别名 | |
| 分子式 | |
| 是否进口 | 否 |
| Description |
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels[1] [2] [3] . |
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| IC50 & Target |
Calcium mobilization[1] |
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| In Vitro |
cADPR (20 nM) elicits a large rapid Ca2+ release in sea urchin eggs homogenates[1] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| In Vivo |
cADPR (100 μM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice[5] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| Formula |
C??H??N?O??P?.X(NH?) |
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| SMILES |
O[C@H]([C@@H]1O)[C@](O[C@]1([H])COP(O)(OP(O)(OC2)=O)=O)([H])N3C(N=CN([C@]4([H])O[C@@]2([H])[C@@H](O)[C@H]4O)C5=N)=C5N=C3.N.[F,Cl,Br,I] |
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| Shipping |
Room temperature in continental US; may vary elsewhere. |
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| Storage |
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| References |
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