产品名称：柯胺G

CAS：6472-91-9

规格：5mg

储存条件：-15℃避光防潮

保质期：24个月

产品物理化学光谱特性

分子量：482.44

溶剂：DMSO

激发波长(nm)：386

发射波长(nm)：N/A

产品介绍

Chrysamine G是刚果红的亲脂性双水杨酸类似物，具有高（Kd = 200 nM； Bmax = 1.13摩尔/摩尔Ab40）和低（Kd = 38.77 μM； Bmax = 23.10摩尔/摩尔Ab40）。 β-淀粉样蛋白（Ab）原纤维的亲和力结合位点。 它可以穿过血脑屏障，并可用作检测老年斑（Ab聚集体）的有用探针。

参考文献

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Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice
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Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
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Journal: J Neuropathol Exp Neurol (2002): 797

Evaluation of 99mTc-MAMA-chrysamine G as an in vivo probe for amyloidosis
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Journal: Amyloid (2001): 202

In search of the ideal radiotracer for soft-tissue amyloid scanning
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Journal: Amyloid (2001): 220

In vitro affinity of 99Tcm-labelled N2S2 conjugates of chrysamine G for amyloid deposits of systemic amyloidosis
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Journal: Nucl Med Commun (2001): 553

Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles
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Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy
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