产品名称：硫代黄素T

CAS：2390-54-7

规格：1g

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：318.87

溶剂：DMSO

激发波长（nm）：412

发射波长（nm）：482

产品介绍

        硫代黄素T是美国AAT Bioquest生产的荧光染料 。硫磺素T（ThT），也称为碱性黄1或CI 49005，是苯并噻唑盐。该染料用于可视化由阿尔茨海默病患者脑中发现的β-淀粉样蛋白组成的斑块。当它与β片层结合时，例如淀粉样蛋白寡聚体中的那些，染料经历其激发光谱的特征性的120nm红移，其可以在450nm处被选择性激发，产生482nm的荧光信号。ThT快速且特异性结合由合成β-淀粉样蛋白（1-40）形成的反平行β-折叠原纤维，但不结合单体或寡聚中间体。ThT的结合不会干扰β-淀粉样肽聚集成淀粉样蛋白原纤维。百

参考文献

Fluorescent dyes in the context of DNA-binding: The case of Thioflavin T
Authors: Alessandro Biancardi, Tarita Biver, Benedetta Mennucci
Journal: International Journal of Quantum Chemistry (2017)

Human Telomeric Hybrid-2-over-Hybrid-1 G-quadruplex Targeting and a Selective Hypersaline-Tolerant Sensor Using Abasic Site-Engineered Monomorphism
Authors: Tao Wu, Meiyun Ye, Tianyi Mao, Fan Lin, Yuehua Hu, Ning Gan, Yong Shao
Journal: Analytica Chimica Acta (2017)

Determinants of amyloid fibril degradation by the PDZ protease HTRA1
Authors: Simon Poepsel, Andreas Sprengel, Barbara Sacca, Farnusch Kaschani, Markus Kaiser, Christos Gatsogiannis, Stefan Raunser, Tim Clausen, Michael Ehrmann
Journal: Nature chemical biology (2015): 862--869

Thioflavin T as a fluorescence probe for monitoring RNA metabolism at molecular and cellular levels
Authors: Shinya Sugimoto, Ken-ichi Arita-Morioka, Yoshimitsu Mizunoe, Kunitoshi Yamanaka, Teru Ogura
Journal: Nucleic acids research (2015): gkv338

Ag nanoclusters as probes for turn-on fluorescence recognition of TpG dinucleotide with a high selectivity
Authors: Jian Peng, Yong Shao, Lingling Liu, Lihua Zhang, Hua Liu, Ying Wang
Journal: Analytica chimica acta (2014): 78--84

Mechanistic aspects of thioflavin-T self-aggregation and DNA binding: evidence for dimer attack on DNA grooves
Authors: A Biancardi, T Biver, A Burgalassi, M Mattonai, F Secco, M Venturini
Journal: Physical Chemistry Chemical Physics (2014): 20061--20072

Molecular rotor-based fluorescent probe for selective recognition of hybrid G-quadruplex and as a K+ sensor
Authors: Lingling Liu, Yong Shao, Jian Peng, Chaobiao Huang, Hua Liu, Lihua Zhang
Journal: Analytical chemistry (2014): 1622--1631

Selective recognition of ds-DNA cavities by a molecular rotor: switched fluorescence of thioflavin T
Authors: Lingling Liu, Yong Shao, Jian Peng, Hua Liu, Lihua Zhang
Journal: Molecular BioSystems (2013): 2512--2519