产品名称：细胞抑制剂(-)-Blebbistatin

CAS：856925-71-8

规格：1mg

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：292.33

溶剂：DMSO

产品介绍

（-）-Blebbistatin是非肌肉肌球蛋白II ATPase的细胞可渗透抑制剂，IC50为2 μM。 它不抑制肌球蛋白轻链激酶，在不破坏有丝分裂或可收缩环组装的情况下，抑制卵裂沟的收缩。

参考文献

Homology model of nonmuscle myosin heavy chain IIA and binding mode analysis with its inhibitor blebbistatin
Authors: Lv Y, Lu S, Lu T, Kou J, Yu B.
Journal: J Mol Model (2013): 1801

The mechanical uncoupler blebbistatin is associated with significant electrophysiological effects in the isolated rabbit heart
Authors: Brack KE, Narang R, Winter J, Ng GA.
Journal: Exp Physiol (2013): 1009

Blebbistatin, a myosin inhibitor, is phototoxic to human cancer cells under exposure to blue light
Authors: Mikulich A, Kavaliauskiene S, Juzenas P.
Journal: Biochim Biophys Acta (2012): 870

Enrichment of cell populations in metaphase, anaphase, and telophase by synchronization using nocodazole and blebbistatin: a novel method suitable for examining dynamic changes in proteins during mitotic progression
Authors: Matsui Y, Nakayama Y, Okamoto M, Fukumoto Y, Yamaguchi N.
Journal: Eur J Cell Biol (2012): 413

Modifications of mechanoelectric feedback induced by 2,3-butanedione monoxime and Blebbistatin in Langendorff-perfused rabbit hearts
Authors: Brines L, Such-Miquel L, Gallego D, Trapero I, Del Canto I, Zarzoso M, Soler C, Pelechano F, Canoves J, Alberola A, Such L, Chorro FJ.
Journal: Acta Physiol (Oxf) (2012): 29

Properties of blebbistatin for cardiac optical mapping and other imaging applications
Authors: Swift LM, Asfour H, Posnack NG, Arutunyan A, Kay MW, Sarvazyan N.
Journal: Pflugers Arch (2012): 503

The role of dynamic instability and wavelength in arrhythmia maintenance as revealed by panoramic imaging with blebbistatin vs. 2,3-butanedione monoxime
Authors: Lou Q, Li W, Efimov IR.
Journal: Am J Physiol Heart Circ Physiol (2012): H262

Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin
Authors: Lawson CP, Slawin AM, Westwood NJ.
Journal: Chem Commun (Camb) (2011): 1057

In vitro and in vivo relaxation of urinary bladder smooth muscle by the selective myosin II inhibitor, blebbistatin
Authors: Zhang X, Kuppam DS, Melman A, DiSanto ME.
Journal: BJU Int (2011): 310

Inhibition of suicidal erythrocyte death by blebbistatin
Authors: Lang E, Qadri SM, Zelenak C, Gu S, Rotte A, Draeger A, Lang F.
Journal: Am J Physiol Cell Physiol (2011): C490