产品名称：巴豆醛-BSA缀合物

规格：100ug

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：N/A

溶剂：水

产品介绍

巴豆醛是一种常见的环境污染物。烟草烟雾是巴豆醛的重要来源。巴豆醛也自然存在于某些水果和蔬菜、精选乳制品和一些酒精的饮料中。除了这些外源性来源外，巴豆醛也是在脂质过氧化（LPO）过程中内生形成的，LPO可能是导致不吸烟者血清中醛类存在的一个因素。与其他不饱和醛一样，巴豆醛具有许多毒理学特性，包括在实验动物中引起多器官毒性的能力；在体外的DNA损伤和致突变性；在体内的致癌性。将巴豆醛加入牛血清白蛋白（BSA）中，制备了巴豆醛-BSA缀合物。我们的巴豆醛-牛血清白蛋白缀合物完全具有巴豆醛/蛋白质的定义比率，这是其他供应商没有提供的。它已用于制备抗巴豆醛抗体和发展巴豆醛定量分析。

参考文献

Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
Authors: Park, Sungshim L and Carmella, Steven G and Chen, Menglan and Patel, Yesha and Stram, Daniel O and Haiman, Christopher A and Le Marchand, Loic and Hecht, Stephen S
Journal: PloS one (2015): e0124841

Tandem catalysis in domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization: concise synthesis of 2,6-cis-substituted tetrahydropyran derivatives.
Authors: Fuwa, Haruhiko and Noguchi, Takuma and Noto, Kenkichi and Sasaki, Makoto
Journal: Organic & biomolecular chemistry (2012): 8108-12

The organocatalytic three-step total synthesis of (+)-frondosin B.
Authors: Reiter, Maud and Torssell, Staffan and Lee, Sandra and Macmillan, David W C
Journal: Chemical science (2010): 37-42

Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein.
Authors: Seiner, Derrick R and LaButti, Jason N and Gates, Kent S
Journal: Chemical research in toxicology (2007): 1315-20

Nucleophilic carbenes as organocatalysts.
Authors: Glorius, F and Hirano, K
Journal: Ernst Schering Foundation symposium proceedings (2007): 159-81

Coupling products of nucleosides with the glyoxal adduct of deoxyguanosine.
Authors: Brock, Angela K and Kozekov, Ivan D and Rizzo, Carmelo J and Harris, Thomas M
Journal: Chemical research in toxicology (2004): 1047-56

Structural and kinetic determinants of aldehyde reduction by aldose reductase.
Authors: Srivastava, S and Watowich, S J and Petrash, J M and Srivastava, S K and Bhatnagar, A
Journal: Biochemistry (1999): 42-54

Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal.
Authors: Iersel, M L and Ploemen, J P and Struik, I and van Amersfoort, C and Keyzer, A E and Schefferlie, J G and van Bladeren, P J
Journal: Chemico-biological interactions (1996): 117-32