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MMP-3 Green 基质金属蛋白酶绿色荧光底物
物品单位 价格 品牌
1272 AAT Bioquest
  • 产地:American
  • 型号:100 Tests
  • 货号:CS13527
  • 发布日期: 2022-03-01
  • 更新日期: 2022-03-23
产品详细说明
产地 American
品牌 AAT Bioquest
货号 CS13527
用途范围 Research Grade
纯度 98%%
CAS编号
规格 100 Tests
是否进口

产品名称:MMP-3 Green 基质金属蛋白酶绿色荧光底物

规格:100 Tests

储存条件:-15℃避光防潮

保质期:12个月

 

产品物理化学光谱特性

分子量:~2200

溶剂:DMF

激发波长(nm):494

发射波长(nm):515

 

产品介绍

基质金属蛋白酶(MMPs)是一个锌依赖性内肽酶家族,在细胞外基质中发挥作用。这些酶在负责结缔组织的分解,在骨重建、月经周期和组织损伤修复中起重要作用。虽然MMPs在某些病理过程中的确切作用尚不清楚,但MMPs似乎在关节炎以及肿瘤的侵袭和转移中起着关键作用。基质金属蛋白酶往往有多种基质,大多数家族成员都有能力降解不同类型的胶原蛋白以及弹性蛋白、明胶和纤连蛋白。很难找到对单一MMP酶有选择性的底物。该FRET底物被设计用于检测MMP-3酶的一般活性。当使用纯化的MMP-3酶时,它也可用于筛选MMP抑制剂。该FRET底物基于我们的tf2/TQ2,MMP Green FRET由于tf2/TQ2 FRET对分离,FRET肽底物增加。荧光增强与MMP酶活性成正比。

 

图示

图1.内部淬火的FRET肽底物被蛋白酶消化以产生高荧光肽片段。荧光增强与蛋白酶活性成正比。

 

参考文献

Zinc ions regulate opening of tight junction favouring efflux of macromolecules via the GSK3β/snail-mediated pathway
Authors: Xiao, Ruyue and Yuan, Lan and He, Weijiang and Yang, Xiaoda
Journal: Metallomics (2018)

Connexin 43 Upregulation by Dioscin Inhibits Melanoma Progression via Suppressing Malignancy and Inducing M1 Polarization
Authors: Kou, Yu and Ji, Liyan and Wang, Haojia and Wang, Wensheng and Zheng, Hongming and Zou, Juan and Liu, Linxin and Qi, Xiaoxiao and Liu, Zhongqiu and Du, Biaoyan and others
Journal: International Journal of Cancer (2017)

DACT2, an epigenetic stimulator, exerts dual efficacy for colorectal cancer prevention and treatment
Authors: Lu, Linlin and Wang, Ying and Ou, Rilan and Feng, Qian and Ji, Liyan and Zheng, Hongming and Guo, Yue and Qi, Xiaoxiao and Kong, Ah-Ng Tony and Liu, Zhongqiu
Journal: Pharmacological research (2017)

Probing Cell Adhesion Profiles with a Microscale Adhesive Choice Assay
Authors: Kittur, Harsha and Tay, Andy and Hua, Avery and Yu, Min and Di Carlo, Dino
Journal: Biophysical Journal (2017): 1858--1867

Inhibition of BET bromodomain attenuates angiotensin II induced abdominal aortic aneurysm in ApoE-/- mice
Authors: Duan, Qiong and Mao, Xiaoxiao and Liao, Chaonan and Zhou, Haoyang and Sun, Zelin and Deng, Xu and Hu, Qiuning and Qi, Jun and Zhang, Guogang and Huang, He and others
Journal: International Journal of Cardiology (2016): 428--432

Tissue inhibitor of metalloproteinase 1 influences vascular adaptations to chronic alterations in blood flow
Authors: M and el, Erin R and Uchida, Cass and ra and Nwadozi, Emmanuel and Makki, Armin and Haas, Tara L
Journal: Journal of Cellular Physiology (2016)

β-adrenoceptors are upregulated in human melanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines
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Journal: Laboratory Investigation (2013): 279--290

Matrix Remodeling Maintains Embryonic Stem Cell Self-Renewal by Activating Stat3
Authors: Przybyla, Laralynne M and Theunissen, Thorold W and Jaenisch, Rudolf and Voldman, Joel
Journal: Stem Cells (2013): 1097--1106

Identification and functional validation of CDH11, PCSK6 and SH3GL3 as novel glioma invasion-associated candidate genes
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Journal: Neuropathology and applied neurobiology (2012): 201--212

EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate carcinoma cells
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Journal: Molecular Cancer Research (2011): 149--160

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