15926423062  

产品展厅

荧光底物Mca-PLAQAV-Dpa-RSSSR-NH2
物品单位 价格 品牌
1836 AAT Bioquest
  • 产地:American
  • 型号:1 mg
  • 货号:CS13560
  • 发布日期: 2022-03-01
  • 更新日期: 2022-03-23
产品详细说明
产地 American
品牌 AAT Bioquest
货号 CS13560
用途范围 Research Grade
纯度 98%%
CAS编号
规格 1 mg
是否进口

产品名称:荧光底物Mca-PLAQAV-Dpa-RSSSR-NH2

规格:1mg

储存条件:-15℃避光防潮

保质期:24个月

 

产品物理化学光谱特性

分子量:1638.96

溶剂:DMSO

激发波长(nm):322

发射波长(nm):381

校正系数(280nm):0.3

 

产品介绍

Mca-PLAQAV-Dpa-RSSSR-NH2是用于检测肿瘤坏死因子-α转换酶(TACE或ADAM17)和相关酶(如ADAM8,ADAM9和ADAM10)的荧光肽底物。其N端包含高荧光的7-甲氧基香豆素(MCA)荧光团,可通过荧光共振能量转移(Dark FRET)通过Dpa上的非荧光2,4-二硝基苯基有效地淬灭。它可用于测量能够裂解荧光基团和淬灭基团之间酰胺键的肽酶活性,从而增加荧光强度。该肽序列衍生自促肿瘤坏死因子-α(TNF-α)。 TACE / ADAM17和ADAM10的切割位点是A(Ala)和V(Val)残基之间的肽键。

 

参考文献

Increased plasma TACE activity in subjects with mild cognitive impairment and patients with Alzheimer's disease.
Authors: Sun, Qiying and Hampel, Harald and Blennow, Kaj and Lista, Simone and Levey, Allan and Tang, Beisha and Li, Rena and Shen, Yong
Journal: Journal of Alzheimer's disease : JAD (2014): 877-86

Primary structure and characterization of a non hemorrhagic metalloproteinase with fibrinolytic activity, from the snake venom of Protobothrops tokarensis (Tokara-habu).
Authors: Oyama, Etsuko and Kitagawa, Yasuyuki and Takahashi, Hidenobu
Journal: Toxicon : official journal of the International Society on Toxinology (2013): 153-61

ADAM-17: the enzyme that does it all.
Authors: Gooz, Monika
Journal: Critical reviews in biochemistry and molecular biology (2010): 146-69

Expression of pro-inflammatory TACE-TNF-α-amphiregulin axis in Sj?gren's syndrome salivary glands.
Authors: Sisto, Margherita and Lisi, Sabrina and Lofrumento, Dario Domenico and Ingravallo, Giuseppe and Mitolo, Vincenzo and D'Amore, Massimo
Journal: Histochemistry and cell biology (2010): 345-53

Constitutive endocytosis of the chemokine CX3CL1 prevents its degradation by cell surface metalloproteases.
Authors: Huang, Yi-Wei and Su, Paul and Liu, Guang Ying and Crow, Min Rui and Chaukos, Deanna and Yan, Harry and Robinson, Lisa A
Journal: The Journal of biological chemistry (2009): 29644-53

Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis.
Authors: Moss, Marcia L and Sklair-Tavron, Liora and Nudelman, Raphael
Journal: Nature clinical practice. Rheumatology (2008): 300-9

Expressions of tumor necrosis factor-converting enzyme and ErbB3 in rats with chronic obstructive pulmonary disease.
Authors: Ju, Chun-rong and Xia, Xi-zheng and Chen, Rong-chang
Journal: Chinese medical journal (2007): 1505-10

Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain.
Authors: Srinivasan, Bhooma and Wang, Zhaohui and Brun-Zinkernagel, Anne M and Collier, Robert J and Black, Roy A and Frank, Stuart J and Barker, Philip A and Roque, Rouel S
Journal: Molecular and cellular neurosciences (2007): 449-61

Relationships between early inflammatory response to bleomycin and sensitivity to lung fibrosis: a role for dipeptidyl-peptidase I and tissue inhibitor of metalloproteinase-3?
Authors: Pottier, Nicolas and Chupin, Cécile and Defamie, Virginie and Cardinaud, Bruno and Sutherland, Rachel and Rios, Géraldine and Gauthier, Francis and Wolters, Paul J and Berthiaume, Yves and Barbry, Pascal and Mari, Bernard
Journal: American journal of respiratory and critical care medicine (2007): 1098-107

Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme.
Authors: Neumann, Ulf and Kubota, Hisashi and Frei, Karl and Ganu, Vishwas and Leppert, David
Journal: Analytical biochemistry (2004): 166-73

< 返回前一个页面 >





联系方式
手机:15926423062
电话:15926423062
手机访问官网

15926423062

武汉科斯坦生物科技有限公司 版权所有(C)2022  XML 技术支持: 食品商务网   盖德化工网  

武汉科斯坦生物科技有限公司