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小沟结合物探针CDPI3琥珀酰亚胺酯
物品单位 价格 品牌
2472 AAT Bioquest
  • 产地:American
  • 型号:1 mg
  • 货号:CS6907
  • 发布日期: 2022-03-01
  • 更新日期: 2022-03-25
产品详细说明
产地 American
品牌 AAT Bioquest
货号 CS6907
用途范围 Research Grade
纯度 98%%
CAS编号
规格 1 mg
是否进口

产品名称:小沟结合物探针CDPI3琥珀酰亚胺酯

规格:1 mg

储存条件:-20℃干燥

保质期:12个月

 

产品物理化学光谱特性

外观:固体

分子量:863.93

溶剂:DMSO

 

产品介绍

小沟结合物(MGB)分子选择性地结合到DNA分子的小沟,即DNA螺旋中的浅沟。MGB标记的寡核苷酸与互补的DNA和RNA靶序列形成稳定的杂合复合物。天然产物CC-1065的类似物二氢吡咯并吲哚三肽(CDPI3)已表现出与寡核苷酸连接时可在单链DNA上阻止序列特异性引物延伸。包含CDPI3的寡核苷酸可提高特异性和杂交强度,从而增强DNA双链体的稳定性。将MGB分子添加到DNA探针可以设计出较短的杂交探针,该探针可用于分子诊断,例如基于定量PCR的测定。可能有几种设计,包括Taqman MGB探针。AAT Bioquest提供此CPG支持,可将MGB部分方便地添加到寡核苷酸的3'末端。我们还提供MGB亚磷酰胺,用于用MGB部分标记5'末端。

  

参考文献

Carbocyclic Analogues of Distamycin and Netropsin.
Authors: Arciszewska, Karolina and Pu?kowska, Anna and Wróbel, Agnieszka and Drozdowska, Danuta
Journal: Mini reviews in medicinal chemistry (2019): 98-113

Synthesis of a novel 4H-pyran analog as minor groove binder to DNA using ethidium bromide as fluorescence probe.
Authors: Ramana, M M V and Betkar, Rahul and Nimkar, Amey and Ranade, Prasanna and Mundhe, Balaji and Pardeshi, Sachin
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2016): 165-71

Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines.
Authors: Ríos Martínez, Carlos H and Lagartera, Laura and Kaiser, Marcel and Dardonville, Christophe
Journal: European journal of medicinal chemistry (2014): 481-91

Classification of DNA minor and major grooves binding proteins according to the NLSs by data analysis methods.
Authors: Amanzadeh, Elnaz and Mohabatkar, Hassan and Biria, Davoud
Journal: Applied biochemistry and biotechnology (2014): 437-51

Multi-spectroscopic and molecular modeling studies on the interaction of antihypertensive drug; methyldopa with calf thymus DNA.
Authors: Shahabadi, Nahid and Maghsudi, Maryam
Journal: Molecular bioSystems (2014): 338-47

Quantitation of substitutions at amino acid 70 in hepatitis C virus genotype 1b.
Authors: Hu, Zhongjie and Liu, Ying and Qiu, Lixia and Fan, Zuopeng and Nie, Wei and Liang, Shan and Jin, Ronghua
Journal: Virology journal (2014): 148

Minor groove binders as anti-infective agents.
Authors: Barrett, Michael P and Gemmell, Curtis G and Suckling, Colin J
Journal: Pharmacology & therapeutics (2013): 12-23

Weight loss effects of quaternary salts of 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles; structure-activity relationships.
Authors: Tercel, Moana and Stevenson, Ralph J and Lu, Guo-Liang and Stribbling, Stephen M and Wilson, William R and Tatnell, Michele A and Marnane, Rebecca N and Mountjoy, Kathleen G and Denny, William A
Journal: Bioorganic & medicinal chemistry (2012): 734-49

Characterization of Canine parvovirus 2 variants circulating in Greece.
Authors: Ntafis, Vasileios and Xylouri, Eftychia and Kalli, Iris and Desario, Costantina and Mari, Viviana and Decaro, Nicola and Buonavoglia, Canio
Journal: Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc (2010): 737-40

Quantification of RNA editing of the serotonin 2C receptor (5-HT(?C)R) ex vivo.
Authors: Lanfranco, Maria Fe and Anastasio, Noelle C and Seitz, Patricia K and Cunningham, Kathryn A
Journal: Methods in enzymology (2010): 311-28

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